CA eLetter to the Editor (Decision)

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Dear colleagues and friends,

The American Cancer Society's cancer journal ("CA") has agreed to e-publish my rebuttal (attached Word document) to their well-publicized article that warned not to mix antioxidants with cancer therapies. That original article got exaggerated headlines telling us not to use supplements or vitamins along with cancer therapies. Click here for that article, in a PDF format

Reviewing the original article, there are 29 references. Two refer to the number of cancer patients who use dietary supplements (50%), three show how "antioxidants can protect cells from radiation and chemotherapy", and the next five refer to evidence that antioxidants show promising evidence to "reduce treatment-related toxicities".

The next five references show that antioxidants "can enhance the effectiveness of chemotherapy and radiotherapy".

That's the first 15 references (out of 29) in a review article lending no substance to the author's conclusions, and in some cases contradicting them.

The next four references refer to mechanisms and the contradictory evidence shown in studies, mostly in vitro (test tube studies).

References 20 and 21 refer to positive clinical studies on using Vitamin C against cancer. Several other references refer to studies showing cancer risks in populations, which have been disputed by experts for methodology flaws or too many variables to be definitive. They did not look at using antioxidants or other nutrients with chemotherapy or radiation.

In fact, only one reference specifically addresses using antioxidants during therapy and the effect on that therapy, which admittedly did not eliminate "many confounding factors". This was supposed to be the whole point of the article!

My rebuttal has 31 to-the-point references.

The original article and my rebuttal are both attached. When they publish my letter on their web site, the Internet address for viewing it should be this link: http://caonline.amcancersoc.org/cgi/eletters?lookup=by_date&days=365

Please note that I have signed the copyright to the journal for publication.

Neil Levin

-----Original Message-----
From: lauren.ransome@cancer.org [mailto:lauren.ransome@cancer.org]
Sent: Wednesday, November 09, 2005 3:58 PM
To: neil.levin@nowfoods.com
Subject: MS No.: CA-0067-05 Version 1

November 09, 2005

Neil E. Levin
NOW Foods
395 S Glen Ellyn Road
Bloomingdale, IL
60108

RE: CA-0067-05 Version 1: Cancer Patients May Very Well Tolerate the Use of Certain Dietary Supplements

Dear Neil E. Levin,

Your eLetter has been ACCEPTED for publication in CA: A Cancer Journal for Clinicians.

If you have any questions, please contact Lauren Ransome, Managing Editor.

Thank you for your excellent submission. I look forward to seeing your article published online.

Sincerely,

Ted S. Gansler, MD, MBA
Editor, CA: A Cancer Journal for Clinicians

-----Original Message-----
Sent: Wednesday, November 09, 2005 1:58 PM
To: neil.levin@nowfoods.com
Subject: CA eLetter to the Editor (Decision) (Please Reply)
Importance: High

Dear Mr. Levin,

I am pleased to inform you that your eLetter has been ACCEPTED for publication on the journal's Web site. In the meantime, the author of the article has been contacted to see if she is interested in posting a reply.

Before we can proceed with publication of your article, however, I will need to receive a signed copy of the CA Copyright Assignment form, which has been attached for your convenience. Please note that all co-authors must sign the agreement before any articles can be posted.

You will also receive a formal decision letter, indicating that your eLetter has been accepted, via Rapid Review, the journal's electronic manuscript tracking system. However, in order for us to upload the article to assign the letter a tracking number, I will need your business address and work and fax number information. You will receive an automated message via Rapid Review that you have been assigned a USERNAME and PASSWORD. At this point, you do not need to do anything. This is a formality, but one that must be done to ensure correct tracking of all of our eLetters.

For future submissions to CA, please feel free to utilize the journal's electronic manuscript tracking system, which is very easy to use. This will provide you with the opportunity to track where your article is in the review process from anywhere in the world.

Thanks so very much for your excellent eLetter, and we look forward to receipt of your faxed, signed agreement at your earliest convenience.

Please feel free to contact me with any questions and thanks so very much for your assistance with this matter. Best wishes,
Lauren Lauren A. Ransome
Managing Editor, CA: A Cancer Journal for Clinicians American Cancer Society
1599 Clifton Road, NE
Atlanta, GA 30329

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